Title Effect of Some Medicinal Plants: Urtica dioica, Viscum album, Eucalyptus globulus and Olea europea on alloxan-induced Diabetic Mice
Authors Yusuf OZAY,Muhammet Kasım CAYCI,Sevda GUZEL,Ebru Gökalp OZKORKMAZ,Vahdettin BAYAZIT
Abstract Current antidiabetic treatments are based on synthetic agents which existing several effects in long term uses.. Therefore, it is needed to develop new and safer pharmaceuticals as alternative for treatment of diabetes. Traditionally used plants are important source of potential antidiabetic agents. In this study four plants used traditionally for treatment of many disease were evaluated for their antidiabetic action.This study was focused on the effects of Urtica dioica(UD),Viscum album(VA), Eucalyptus globulus(EG) and Olea europea(OE) extract on blood and organ glucose concentrations of hyperglycemic mice. Hyperglycemia was induced by alloxan and the antidiabetic drug glutril used for the comparison. Aqueous extracts of UD, VA,EG and OE and glutril were given three drops orally every day and blood glucose levels were measured in two days interval at eight periods.It was found that blood glucose concentrations of UD, VA, EG, OE and glutril groups were 90.9±3.9 mg/dl, 95.2±2.4 mg/dl, 75.3±3.1 mg/dl, 93.7±2.7 mg/dl and 96.3±2.3 mg/dl, respectively (P<0.001). The all tested plants were decreased fasting blood glucose levels similar to antidiabetic agent glutril. Additionally, no adverse effects were determined in plant extracts treated groups. Further investigation is needed to determine constituents which is responsible from activity and these plants can be use as alternative therapeutics.
Keywords Hyperglycemia, Urtica dioica, Viscum album, Eucalyptus globulus, Olea europea, traditional medicine
Journal BIBAD - Research Journal Of Biological Sciences
Issue Issue 1
Page 001-007
Year 2016
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