Title Effects of Nifedipine on Histology of Small Intestine
Authors Canan AKGÜL, Haluk ÖZPARLAK, İlhami ÇELİK, Yasemin ÖZNURLU
Abstract Nifedipine is a calcium channel blocker that primarily blocks L-type calcium channels. The aim of this study was to evaluate effects on histology of small intestine of high dose nifedipine, which was administered to the rats for 30 days and also effects of the cessation of the administration after 40 days. The rats were divided into control (n=16) and nifedipine (n=16) groups at the beginning of the study. Standard rat feed containing 125 mg\kg powdered nifedipine was given to the nifedipine group everyday for one week. During the following three weeks, 250 mg\kg nifedipine was given to the rats with the same method. On the 30th and 70th days of the study, histologic sections were obtained from the tissue samples of small intestine. The histological changes occurring in the small intestine were evaluated and histomorphometric measurements were performed under the light microscope. Goblet cells were also evaluated in the sections stained with periodic-acid Schiff (PAS) method. A statistically significant (p<0.05) decrease was observed in the villus area of the small intestine of the nifedipine-administered group. It was concluded that the decrease of the villus area might have arisen from atrophy depending on the side effects of nifedipine. Regression in atrophy was observed in the nifedipine-ceased group.
Keywords Calcium channel blocker, Nifedipine, PAS, Small intense
Journal BIBAD - Research Journal of Biological Sciences
Issue Issue 1
Page 011-018
Year 2015
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